Inhibitory action of some organotin complexes to colibacillus were researched by microcalorimetry in thermokinetic analysis; the result indicate that the organotin complexes had good antibacterial activities, some of them were 100 times than penicillin. 用微量量热法研究了代表性有机锡配合物对大肠杆菌的抑制作用,结果显示所制备的有机锡配合物均具有很好的杀菌活性,某些化合物的杀菌活性要比青霉素强100多倍。